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2019-3-14 · T cells and Natural Killer (NK) cells are major effectors of antitumor immune responses [1, 2].Immunotherapies aimed at enhancing their activity have now reached bedside, with some outstanding effects reported in melanoma, breast or kidney cancers [3, 4].Nevertheless, large proportions of patients fail to respond to these treatments [] while other …

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2018-3-30 · These antibodies inhibited tumor growth in multiple fully immunocompetent mouse models and reduced human melanoma metastases in a humanized mouse model. Antitumor immunity was mediated mainly by natural killer (NK) cells through activation of NKG2D and CD16 Fc receptors. This approach prevents the loss of important immunostimulatory ligands by ...

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