y pestis iron importer system

Hierarchy of iron uptake systems: Yfu and Yiu are …

The cloned yiuABC operon restored growth of an enterobactin-deficient mutant Escherichia coli strain, 1017, under iron-chelated conditions. Iron uptake by the Yiu system in Y. pestis was demonstrated only when the Ybt, Yfe, and Yfu systems were mutated. Using a yiuA::lacZ fusion, we show that the yiuABC promoter is repressed by iron through Fur.

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2  · Plasmid-mediated high-level resistance to multiple antibiotics was reported in a clinical isolate of Yersinia pestis in Madagascar in 1997 ... it becomes quite vulnerable to corruption These errors are known to occur when the number of data sets that the SAS system has open exceeds the number of files that the operating system allows to be open ...

Role of the Yersinia pestis Yersiniabactin Iron Acquisition …

2010-12-17 · Effect of the Y. pestis Ybt on transmission by fleas. Incidence and time to terminal disease in mice bitten by fleas infected with Y. pestis wild type (open squares) or …

Iron availability and oxygen tension regulate the Yersinia …

2019-12-23 · The enteropathogen Yersinia pseudotuberculosis and the related plague agent Y.pestis require the Ysc type III secretion system (T3SS) to subvert phagocyte defense mechanisms and cause disease. Yet type III secretion (T3S) in Yersinia induces growth arrest and innate immune recognition, necessitating tight regulation of the T3SS. Here we show that Y. ...

Characterization of the Yersinia pestis Yfu ABC inorganic …

To test the role played by this regionP!.0001 in pathogenesis, 3 different deletion mutants (NTUH-K2044 [Dkfu], K2044 [DORF7–9], and K2044 [DPTS]) were constructed. Only the DkfuABC mutants showed decreased virulence in mice, compared with the wild-type strain. An in vitro assay confirmed the involvement of kfu in iron acquisition.

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2019-3-1 · As the bacterial agent of bubonic and pneumonic plague, Y. pestis possesses several iron acquisition systems for its survival in various iron-deficient niches. It acquires inorganic iron via an iron and manganese uptake system or through the secretion of a siderophore called "yersiniabactin" [8,9]. Hemin molecule located at periplasmic can ...

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Znu Is the Predominant Zinc Importer in Yersinia pestis …

2010-9-20 · Iron transport systems in Y. pestis have been extensively characterized and the Ybt siderophore-dependent system has been shown to be essential for the pathogenesis of bubonic plague and to be important for the pathogenesis of pneumonic plague (31, 37). A second system, Yfe, transports both Fe and Mn; Fe uptake by this system is inhibited by ...

The Yfe system of Yersinia pestis transports iron and …

2017-10-2 · In Y. pestis, the causative agent of bubonic plague, the Molecular Microbiology (1999) 32(2), 403–414 Q 1999 Blackwell Science Ltd Received 15 October, 1998; revised 21 December, 1998; accepted 26 January, 1999. *For correspondence. ... potential iron acquisition systems are functioning to allow

The Yfe system of Yersinia pestis transports iron and …

2002-3-1 · Iron acquisition in Yersinia pestis is fundamental to the success of plague pathogenesis. We have previously identified an ≈5.6 kb region (yfe) of Y. pestis genomic DNA, capable of restoring iron-deficient growth but not siderophore production to an Escherichia coli mutant (SAB11) incapable of synthesizing the siderophore, enterobactin.The yfe locus of Y. …

The Yfe system of Yersinia pestis transports iron and …

In addition, compared with its ybt +, yfe + parent, a ybt +, ΔyfeAB mutant of Y. pestis had an ≈100‐fold increase in the LD 50 from a subcutaneous route of infection. These data suggest that the Yfe and Ybt systems may function effectively to accumulate iron during different stages of the infectious process of bubonic plague.

The role of transition metal transporters for iron, zinc, …

2015-6-1 · Y. pestis iron transport systems that are proven functional in vitro.These include a heme transporter (Hmu), three ferrous transporters (Yfe, Feo, and, Fet), three "ferric" transporters (Yfe, Yfu, and Yiu), one siderophore-dependent system (Ybt) fully functional in all Y. pestis biotypes, one system (Fhu/IutA/Fcu) capable of transporting, but not synthesizing aerobactin …

Role of the Yersinia pestis yersiniabactin iron acquisition …

2010-12-17 · Plague is a flea-borne zoonosis caused by the bacterium Yersinia pestis.Y. pestis mutants lacking the yersiniabactin (Ybt) siderophore-based iron transport system are avirulent when inoculated intradermally but fully virulent when inoculated intravenously in mice. Presumably, Ybt is required to provide sufficient iron at the peripheral injection site, suggesting …

Yersiniabactin iron uptake: mechanisms and role in …

2011-5-12 · Although Y. pestis has a second TonB-like gene (hasB), HasB cannot substitute for TonB in iron uptake via the Ybt system [11, 13, 39–41]. In a deferrated, defined medium, a Y. pestis psn mutant shows greater defects in growth (Fig. 3) and uptake of iron when compared to a Y. pestis irp2 mutant.

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Roles of the Yfe and Feo transporters of Yersinia pestis in …

2007-1-6 · In Yersinia pestis, the Yfe and Feo systems likely function to transport ferrous iron.Both FeoA and FeoB are essential for iron acquisition activity while FeoC is not. Mutations in yfe and feo had an additive effect on microaerophilic growth under iron-chelating conditions.Y. pestis cells lacking the Ybt siderophore-dependent system, the Yfe or the Feo system grow …

The Yfe system of Yersinia pestis transports iron and …

In addition, compared with its ybt+, yfe+ parent, a ybt+, DeltayfeAB mutant of Y. pestis had an approximately 100-fold increase in the LD50 from a subcutaneous route of infection. These data suggest that the Yfe and Ybt systems may function effectively to accumulate iron during different stages of the infectious process of bubonic plague.

Roles of the Yfe and Feo transporters of Yersinia pestis in …

2007-1-6 · In Yersinia pestis, the Yfe and Feo systems likely function to transport ferrous iron. Both FeoA and FeoB are essential for iron acquisition activity while FeoC is not. Mutations in yfe and feo had an additive effect on microaerophilic growth under iron-chelating conditions. Y. pestis cells lacking the Ybt siderophore-dependent system, the Yfe or the Feo system grow normally …

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2016-2-11 · Yersinia pestis is a zoonotic pathogen that is most commonly transmitted through fleas that feed on infected rodents. Y. pestis is a Gram-negative, non-motile, non-spore-forming coccobacillus that is also a facultative …

Proteomic analysis of iron acquisition, metabolic and …

2010-1-29 · Background: The Gram-negative bacterium Yersinia pestis is the causative agent of the bubonic plague. Efficient iron acquisition systems are critical to the ability of Y. pestis to infect, spread and grow in mammalian hosts, because iron is sequestered and is considered part of the innate host immune defence against invading pathogens.

Hierarchy of iron uptake systems: Yfu and Yiu are …

2006-9-5 · Europe PMC is an archive of life sciences journal literature. In addition to the yersiniabactin (Ybt) siderophore-dependent system, two inorganic iron ABC transport systems of Yersinia pestis, Yfe and Yfu, have been characterized.Here we show that the Yfu system functions in Y. pestis: a Ybt − Yfe − Yfu − mutant exhibited a greater growth defect under iron …

Role of the Yersinia pestis Yersiniabactin Iron Acquisition …

2010-12-17 · Using a flea-to-mouse transmission model, it is shown that a Y. pestis strain lacking the Ybt system causes fatal plague at low incidence when transmitted by fleas, and new evidence is provided that primary septicemic plague is a distinct clinical entity. Plague is a flea-borne zoonosis caused by the bacterium Yersinia pestis. Y. pestis mutants lacking the yersiniabactin …

Role of the Yersinia pestis Yersiniabactin Iron Acquisition …

2010-12-17 · Plague is a flea-borne zoonosis caused by the bacterium Yersinia pestis. Y. pestis mutants lacking the yersiniabactin (Ybt) siderophore-based iron transport system are avirulent when inoculated intradermally but fully virulent when inoculated intravenously in mice. Presumably, Ybt is required to provide sufficient iron at the peripheral injection site, suggesting …

Characterization of the Yersinia pestis Yfu ABC inorganic …

The yersiniabactin (Ybt) system is a siderophore-dependent transport system required for full virulence. Yfe is an ABC transport system that accumulates both iron and manganese. We have identified and cloned a Y. pestis yfuABC operon. The YfuABC system is a member of the cluster of bacterial ABC iron transporters that include Sfu of Serratia ...

Disruption of the NlpD lipoprotein of the plague pathogen …

2019-6-6 · To uncover the role of NlpD in Y. pestis pathogenicity, we conducted a whole-genome comparative transcriptome analysis as well as phenotypic and virulence evaluation analyses of the nlpD and related mutants. The study reveals a new role for the Y. pestis NlpD lipoprotein in iron assimilation and Tat system activity.

The Yfe system of Yersinia pestis transports iron and …

The data suggest that the Yfe and Ybt systems may function effectively to accumulate iron during different stages of the infectious process of bubonic plague. Iron acquisition in Yersinia pestis is fundamental to the success of plague pathogenesis. We have previously identified an ≈5.6 kb region (yfe) of Y. pestis genomic DNA, capable of restoring iron‐deficient growth but not …

The Yersinia pestis siderophore, yersiniabactin, and the …

In Y. pestis, the Ybt siderophore‐dependent iron uptake system has been shown to have a primary role in iron acquisition in vitro and to be essential for the development of bubonic plague and critical in pneumonic plague (Fetherston et al., 2010; Perry and Fetherston, 2011) on uptake via the Ybt system requires the TonB‐dependent OM receptor Psn, TonB and the IM ABC …

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Role of the Yersinia pestis Yersiniabactin Iron Acquisition …

Plague is a flea-borne zoonosis caused by the bacterium Yersinia pestis. Y. pestis mutants lacking the yersiniabactin (Ybt) siderophore-based iron transport system are avirulent when inoculated intradermally but fully virulent when inoculated intravenously ...

role of transition metal transporters for iron, zinc, …

Y. pestis iron transport systems that are proven functional in vitro.These include a heme transporter (Hmu), three ferrous transporters (Yfe, Feo, and Fet), three "ferric" transporters (Yfe, Yfu, and Yiu), one siderophore-dependent system (Ybt) fully functional in all Y. pestis biotypes, one system (Fhu/IutA/Fcu) capable of transporting, but not synthesizing aerobactin and …

Iron Transport and Regulation in Yersinia Pestis

2006-4-1 · Y. pestis encodes nine potential inorganic iron transport systems and two heme/hemoprotein transport systems. Of these, the siderophore-dependent yersiniabactin (Ybt) iron transport system and the Yfe ABC transporter are the most important systems for acquisition of inorganic iron. Ybt is essential in the early stages of bubonic plague and ...

Bacterial ABC transporters of iron containing compounds

2019-11-1 · Before doing so, it is however worth mentioning the YbtP-YbtQ case from Y. pestis which is involved in iron acquisition by an unknown mechanism. Both YbtP and YbtQ represent fused TMD-ABC modules, and are closer to exporters than to importers, yet are required for iron entry in Y. pestis and for virulence in a mice model. It is not known at ...

Hierarchy of Iron Uptake Systems: Yfu and Yiu Are …

2006-9-5 · a Y. pestis strains lacking pCD1Ap are avirulent due to lack of this low-calcium-response plasmid. Strains with a plus sign possess an intact 102-kb pgm locus containing the genes for biofilm formation (hms) and the Ybt iron transport system.All other Y. pestis strains have either a pgm deletion or a mutation within the pgm locus. Abbreviations Ap r, Km r, Sm r, and …

Adaptive response of Yersinia pestis to extracellular …

2006-8-1 · Among the Y. pestis genes most highly expressed in the bubo were those for known virulence factors, such as the antiphagocytic F1 protein capsule, a plasminogen activator required for systemic invasion from the lymph node, the iron acquisition system encoded on the Y. pestis pathogenicity island, and the TTSS (Table 1, which is published as ...

An ABC Transporter System of Yersinia pestis Allows …

ABSTRACT The acquisition of iron is an essential component in the pathogenesis of Yersinia pestis, the agent of bubonic and pneumonic plague. A cosmid library derived from the genomic DNA ofY. pestis KIM6+ was used for transduction of anEscherichia coli mutant (SAB11) defective in the biosynthesis of the siderophore enterobactin. Recombinant plasmids which had a …

Hierarchy of Iron Uptake Systems: Yfu and Yiu Are …

2006-12-1 · Effect of yfu and yiu mutations on iron-deficient or iron-chelated growth of Y. pestis strains in a Ybt Yfe background. Y. pestis strains were grown in …